Peptide glossary · Structure and synthesis
Deletion sequence
A synthesis by-product missing one or more amino acids. Deletion sequences are very similar to the target peptide and often appear right next to the main peak in HPLC.
In the lab
Because deletion sequences are so similar to the target, only good separation removes them. Their share largely sets the HPLC purity.
More terms: Structure and synthesis
- AcetylationAdding an acetyl group, usually at the N-terminus.
- Aib (aminoisobutyric acid)A non-proteinogenic amino acid with two methyl groups on the alpha carbon.
- AmidationReplacing the C-terminal carboxyl group with an amide.
- AnalogueA molecule that resembles a natural model but is changed on purpose, for example by swapping amino acids or adding a side chain.
- C-terminusThe end of a peptide with the free carboxyl group, on the right of the sequence.
- D-amino acidThe mirror image of the natural L-amino acid.
For laboratory research use only. Not for use in humans or animals.