Peptide glossary · Structure and synthesis
C-terminus
The end of a peptide with the free carboxyl group, on the right of the sequence. Many peptides carry an amide there instead of the acid, shown as -NH2 in the sequence.
In the lab
A free C-terminus carries a negative charge at neutral pH. If it is amidated, that charge disappears, which can change solubility.
More terms: Structure and synthesis
- AcetylationAdding an acetyl group, usually at the N-terminus.
- Aib (aminoisobutyric acid)A non-proteinogenic amino acid with two methyl groups on the alpha carbon.
- AmidationReplacing the C-terminal carboxyl group with an amide.
- AnalogueA molecule that resembles a natural model but is changed on purpose, for example by swapping amino acids or adding a side chain.
- D-amino acidThe mirror image of the natural L-amino acid.
- Deletion sequenceA synthesis by-product missing one or more amino acids.
For laboratory research use only. Not for use in humans or animals.